Lithium Monitoring by Reverse Iontophoresis in Vivo
نویسندگان
چکیده
منابع مشابه
Lithium monitoring by reverse iontophoresis in vivo.
BACKGROUND We investigated reverse transdermal iontophoresis as an alternative, noninvasive method for lithium monitoring in vivo. The objectives of such an approach would be to facilitate compliance with treatment and to improve the quality of life for bipolar patients. METHODS We studied 23 bipolar or schizo-affective patients. Over a 2-h period, we extracted lithium and other cations acros...
متن کاملTherapeutic Drug Monitoring By Reverse Iontophoresis
Therapeutic molecules possessing distinct pharmacokinetic variation, narrow therapeutic index and concentration dependent therapeutic/adverse effects demand constant monitoring. The current methods for blood sampling are invasive and possess low patient compliance. Human skin, selective and effective membrane to chemical permeation, offers an alternative route for the extraction of endogenous m...
متن کاملNon-invasive diagnosis and monitoring of chronic kidney disease by reverse iontophoresis of urea in vivo.
BACKGROUND Reverse iontophoresis uses a small current to extract molecules and ions through the skin. The aim of the study was to determine whether reverse iontophoresis of urea can be used (i) to diagnose and monitor non-invasively chronic kidney disease (CKD), and (ii) to track urea levels closely during a hemodialysis session. METHODS A current of 0.8mA was applied for 2h in 10 healthy vol...
متن کاملResearch Paper Monitoring of Urea and Potassium by Reverse Iontophoresis In Vitro
Purpose. Reverse iontophoresis is an alternative to blood sampling for the monitoring of endogenous molecules. Here, the potential of the technique to measure urea and potassium levels non-invasively, and to track their concentrations during hemodialysis, has been examined. Materials and Methods. In vitro experiments were performed to test (a) a series of subdermal urea and potassium concentrat...
متن کاملCortisol extraction through human skin by reverse iontophoresis.
Continuous monitoring of cortisol at the surface of the skin would advance the diagnosis and treatment of cortisol-related diseases, or of elevated cortisol levels related to stress in otherwise healthy populations. Reliable and accurate detection of cortisol at the skin surface remains a limiting factor in real-time monitoring of cortisol. To address this limitation, cortisol extraction throug...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2004
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2004.034249